It should be mentioned that a portion of the amphetamine isomers within Adderall undergo additional metabolism to form metabolites such as: benzoic acid (20%), benzyl methyl ketone (3%), and p-hydroxy-amphetamine (3%). The levoamphetamine should be eliminated from your system within 60.5 to 77 hours (~2.52 to ~3.2 days). Knowing the respective half-lives of the amphetamine salt constituents, we can estimate that dextroamphetamine should be eliminated from your system within 55 to 66 hours post-ingestion (~2.29 to ~2.75 days). The dextroamphetamine isomer exhibits an elimination half-life of 10 to 12 hours, whereas the levoamphetamine isomer exhibits an elimination half-life of 11 to 14 hours. To calculate how long Adderall stays in your system once you’ve quit, the first step is to examine the half-lives of its amphetamine isomer constituents, dextroamphetamine and levoamphetamine, respectively.
In the early stages of quitting the drug, you’ll likely experience an initial Adderall crash, followed by Adderall withdrawal, and possibly a Post Acute Withdrawal Syndrome (PAWS) if you were a heavy user or abused it. Within the first few days of quitting, you may feel as though you’ve transformed from a functioning, energetic human being to a complete zombie this is completely normal. How long does Adderall stay in your system? (~3.2 days)Īssuming you’ve taken your final Adderall tablet or capsule, you’re probably wondering how long it’ll take to fully clear the drug from your system. If you’ve quit using the medication, you may want to be cognizant of how long Adderall stays in your system after your final dose (continue reading to get an accurate estimation). Others that have been using Adderall illicitly may quit taking it in fear that they may fail an upcoming drug test. The drug is also used illicitly as a performance enhancer (academically and athletically), as well as a “party drug” among those attempting to attain stimulatory intoxication.Īlthough a subset of individuals with ADHD and narcolepsy may consider Adderall to be a highly effective treatment, some will end up discontinuing the medication as a result of an inability to cope with side effects and/or long-term effects. In addition to its FDA approved indications, Adderall is sometimes prescribed off-label as an intervention for refractory cases of depression and atypical anxiety in which dopaminergic dysfunction is implicated. Though its popularity may eventually fade, the name “Adderall” remains widely recognized among current-market ADHD medications, and arguably all pharmaceutical drugs. The medication is manufactured in multiple formats including: an immediate release (IR) tablet (delivering 4 to 6 hours of effect) and an extended release (XR) encapsulation (yielding 8 to 12 hours of effect). It was first approved by the FDA in 1996 for the management of ADHD (attention-deficit/hyperactivity disorder) and was later approved for the treatment of narcolepsy. Adderall is a prescription medication manufactured by Shire Pharmaceuticals containing a mixture of amphetamine salts (75% dextroamphetamine and 25% levoamphetamine).
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